With the continuous growth in power demand, the connection schemes for new and expanded substations have become increasingly important. This chapter aims to optimize the 110 kV feeder connection scheme for new/expanded substations by analyzing the surrounding 220 kV substations and their 110 kV feeders, classifying various types of lines. The study first collects data on the current and planned grid framework and systematically analyzes the incoming lines. Then, based on line combination strategies, an optimal scheme set suitable for new and expanded sites is developed, ensuring the exclusion of same-level power sources and unsuitable combinations. Finally, the reliability and economic viability of the connection schemes are evaluated, providing theoretical support and practical guidance for the safe and stable operation of the power system. The research findings of this chapter hold significant importance for the planning and construction of power infrastructure.