This chapter introduces information fields \(\left( {\Psi_{I} } \right)\) as a fundamental physical primitive, proposing a unified framework to explain phenomena where information propagates independently of energy. Traditional physics, grounded in matter and energy, struggles to account for quantum nonlocality, biological coherence, cognitive binding, and psychic correlations—all of which exhibit organizational propagation without measurable energy transfer. \(\Psi_{I}\) is defined as a spacetime-filling, causal field that mediates pure organization (phase, topology, and symmetry) across scales, governed by principles of topological invariance and scale symmetry. Theoretical foundations are anchored in empirical evidence, including Bohm’s quantum potential, Montagnier’s DNA solitons, and Azevedo’s Faraday-caged autonomic synchrony. A Lagrangian formalism for \(\Psi_{I}\) is developed, featuring a nonlocal kernel \(G\left( {x,x^{\prime}} \right)\) that quantifies instantaneous correlations, resolving Bell inequality violations, and biological signaling. \(\Psi_{I}\) bridges quantum, biological, and cognitive domains, challenging Wheeler’s “It from Bit” with a “Bit from Field” ontology, where information is physically instantiated by field geometry. Key implications include: (1) Nonlocal coherence: \(\Psi_{I}\) explains entanglement and cross-brain synchrony via topological links (ER = EPR); (2) Energy-form decoupling: Biological systems (e.g., microtubules) exploit \(\Psi_{I}\) ’s phase gradients for noise-free communication; (3) Testable predictions: From angle-dependent Bell tests to CMB topological defects. By unifying information and physics, \(\Psi_{I}\) redefines reality’s architecture, positioning humans as active participants in a field-mediated cosmos. The framework calls for experimental validation and paradigm shifts in quantum biology, neuroscience, and cosmology.