Noise generated by the distribution transformers is an incredibly significant component of the ambient noise in the electrical transmission facility and utility. The transformer’s core vibration, resulting from the magnetostriction property of its material, is the significant source of noise. This research paper elucidates a comprehensive multiphysics simulation approach that has been devised to simulate the magnetostriction, vibration, and acoustic mechanisms responsible for noise generation in the core of a transformer. This methodology also encompasses the transmission of these vibrations through the windings and busbars to the transformer tank. Furthermore, it evaluates the sound power level of the transformer, thereby offering a holistic understanding of noise generation and propagation within transformers. This study gives a way to combine all three physics (magnetics, vibration, and acoustics analysis) in one integrated workflow in ANSYS® and Simcenter 3D® and its validation with the test. Distribution transformer noise at no-load condition is the main contributor to the overall noise of transformer. Magnetostriction analysis done to evaluate the magnetic forces in core along with their frequency content. Harmonic analysis conducted to evaluate the displacements of the core along with the peripheral components. Finally, displacements on the transformer tank outer surface generate sound noise in the surrounding air medium. The test setup uses microphones as per IEC 60076-10:2016 in acoustics analysis model and evaluates the maximum sound power level in audible frequency range. Four different transformer designs ranging from 0.63 to 4.4 MVA are used to validate this approach with the test data, with correlation of ~ 95%. This paper also highlights the sensitivity of parameters like magnetostriction of core, (~ 10 dB noise level reduction with 50% reduction of magnetic strain), sheet thickness, with and without coolant medium, and clamping torque of tie rods on transformer’s noise.