Hysterectomy is considered one of the most common non-pregnancy-related major surgery performed on women. Studies on hysterectomy in developing countries are limited with many restrictions contributing to it. The developed countries report high prevalence in comparison to the developing countries like India reporting low prevalence. The primary aim of the paper is to examine the national and state-level prevalence of hysterectomy among women aged 40 and above and understand the association of socio-demographic factors, lifestyle habits, and pregnancy history over the individuals undergoing hysterectomy. The Longitudinal Ageing Study in India Wave-1 (2020), a nationally representative survey was used for the study. It is a cross-sectional, national survey of scientific investigation of the health, economics and social determinants of population ageing in India. The survey covered 72,250 older adults, whereas, for the study, females with age 40 or above were considered; thus, we have a sample size of 39,309. Bi-variate and multivariate analysis were carried out to achieve the study objectives. Women in the age group 40–50 have mostly undergone hysterectomy (12.7%), which also shows a decreasing prevalence with increasing age. Medical conditions like excessive bleeding (33.6%) be the leading cause of the undergone cases. The odds show that women residing in the urban area are 1.23 times and who belongs to the richest households are 2.16 times more likely to undergo hysterectomy than the rural area and poorer women. The main contributor to the rural–urban differential is the number of pregnancies, wealth, social-group, and lifestyle factors. Undergoing hysterectomy is not mandatory for all cases; unless it is extremely life-threatening which need to made aware of along with other gynaecological morbidities. Measures are needed to ensure suitable and treatment options availed among the respective age groups which are accessible, affordable, and of better quality.