South Africa’s stance regarding the Ukraine-Russia conflict and Israel-Hamas conflict that led to the South African government taking Israel to the International Court of Justice (ICJ) on a charge of genocide could leave the country isolated from its traditional economic partners. This position on Israel has invoked a response from the United States (US) that has led to aid suspension and degeneration of diplomatic relations between the two countries. This can be followed by trade suspension, capital flight, and investment strikes from the US and its allies. This can be offset by global south countries such as India with the 5th biggest economy in the world. However, despite their historical relations and membership in similar multilateral organizations, bilateral trade between South Africa and India is not huge at slightly above US$ 18 billion as of 2023 in favour of India. It is against this background that this paper through South-South Cooperation theory and decoloniality critically analyses India-South Africa relations. The paper argues that current bilateral trade between the two countries is characterised by unequal trade, dominated by raw materials from South Africa to India and a trade deficit in favour of India. However, there are potential areas of expansion regarding trade that will ensure that both countries take advantage of the African Continental Free Trade Area (AfCFTA). Moreover, the paper argues that there is a need for a relationship that will foster equality and partnership between both countries to ensure the successful implementation of AfCFTA.