Rapid urbanization and growing environmental challenges highlight the need for innovative, integrated solutions to combat climate change. In this context, the rise of smart cities and AI-driven smart sustainability represents a transformative approach to tackle climate change and promote sustainable urban development. The chapter conducts a comparative study of China, Malaysia, and Egypt, each with its unique circumstances in applying AI to combat climate change through smart sustainability. China and Malaysia are major contributors of greenhouse gas emissions in Asia, so it is meaningful to navigate the path of both countries to mitigate climate change through innovative solutions supported by Artificial Intelligence. China benefits from a unified national strategy for developing and applying AI in climate change mitigation, particularly in smart city development, energy optimization, and intelligent transportation systems. Malaysia is deploying smart energy systems powered by IoT and AI, while also building smart cities, reducing carbon footprints and enhancing sustainability. Unlike China and Malaysia, Egypt is in an arid region with scarce natural resources and heightened vulnerability to climate change. Efforts in Egypt emphasize developing smart cities, featuring many smart building projects that promote green construction and sustainability. This study also points out AI’s limitations, such as AI-induced energy consumption, data limitations, and ethical considerations, which must be addressed to unlock AI’s full potential in creating sustainable and climate-resilient cities.