Globally, remediation towards clean and potable water resources are a major concern due to rapid industrialization and subsequent pollution. Steady increase in the world population and enormous energy consumption has led to immense industrialization leading to persistent release of toxins and pollutants into the atmosphere and water resources that leads to various health hazards, global warming and climatic changes affecting the liveable eco-system. To address these serious issues, clean, sustainable, efficient, and cost-effective technologies are the need of the hour. This chapter discusses the application of ZnO tetrapods in photocatalytic degradation, towards environmental remediation outlining the general mechanism involved with a brief outline of various photocatalytic reactors, working principles, their design and how ZnO is integrated into it. This chapter also gives a brief overview of ZnO tetrapod’s shape, arm geometry, and surface morphology aspects towards excellent catalytic performance under UV light, visible light and sunlight, highlighting the feasibilities for wastewater treatment.