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Organ transplantation has revolutionized the treatment of end-stage organ failure, offering patients a chance at extended survival and improved quality of life. However, the success of transplantation is heavily dependent on the compatibility between donor and recipient, particularly in terms of human leukocyte antigen (HLA) matching. HLAs are highly polymorphic molecules that play a critical role in immune system recognition. Mismatches in HLA alleles can lead to graft rejection, necessitating accurate HLA typing for optimal donor selection. This review discusses the significance of HLA in transplantation, methods of HLA typing, and its impact on graft survival and immunosuppressive therapy.

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HLA Loci and Typing in Solid Organ Transplantation: A Case-Based Approach to HLA Typing and Applications in Clinical Practice

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  • 发表日期：

    2025年

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  • Shruti Tapiawala,
  • Dolly Daniel,
  • Suchita Jogale

摘要

Organ transplantation has revolutionized the treatment of end-stage organ failure, offering patients a chance at extended survival and improved quality of life. However, the success of transplantation is heavily dependent on the compatibility between donor and recipient, particularly in terms of human leukocyte antigen (HLA) matching. HLAs are highly polymorphic molecules that play a critical role in immune system recognition. Mismatches in HLA alleles can lead to graft rejection, necessitating accurate HLA typing for optimal donor selection. This review discusses the significance of HLA in transplantation, methods of HLA typing, and its impact on graft survival and immunosuppressive therapy.