Single barge unilateral salvage method is more and more used in the overall salvage of large tonnage shipwrecks, which as a multi-body system has complex hydrodynamic characteristics, especially in the application of deep water needs further research. This paper is based on three-dimensional potential flow theory, with the help of hydrodynamic analysis software Moses simulation single barge unilateral salvage method in deep water during the overall salvage of large-tonnage shipwrecks, the barge and the shipwreck’s response to the movement of different sea conditions, according to the results of the calculation of the analysis of the single barge unilateral salvage method applicable to the operating conditions at sea. The results of this study have certain reference value for the selection of operating conditions in the design of single barge unilateral salvage method.