Withdrawal syndrome is characterized by a range of physiological and psychological symptoms, and it poses a significant challenge during recovery from substance use disorders. This chapter delves into the neurobiological mechanisms underlying withdrawal symptoms and examines the potential role of nutrition in their management. Specific nutrients, such as omega-3 fatty acids, amino acids, and micronutrients, are highlighted for their impact on neurotransmitter regulation, inflammation, and stress response pathways, all of which are implicated in the withdrawal process. Practical dietary strategies and evidence-based recommendations are presented to support individuals in mitigating the severity of withdrawal and enhancing recovery outcomes. By integrating nutritional approaches into withdrawal management, this chapter underscores the potential of diet as a complementary tool in the treatment plans, providing insights into nutrition therapy during detoxification as a pathway toward improved health and recovery success.