Food allergies and intolerances are not just about physical symptoms; they can also deeply affect mental health, contributing to conditions like anxiety, depression, and mood disorders. This chapter explores how food allergies and intolerances affect mental well-being, focusing on the role of inflammation, the gut-brain axis, and the immune response. We discuss management strategies, including elimination diets, nutritional interventions, and the use of probiotics and prebiotics, to help mitigate these impacts. By understanding and addressing these interconnected issues, healthcare providers can offer a more holistic approach to improving both physical and mental health for those affected.