In response to the problem of performance degradation or even failure of laser gyroscopes due to the discolouration and blackening of the colour core in microcrystalline glass under irradiation environments, a novel approach is proposed. This approach utilizes the excellent radiation resistance and light transmission properties of high-purity quartz glass, combined with the low thermal expansion and low helium permeability of microcrystalline glass, to solve the problem. Through titanium dioxide doping, the linear expansion coefficient of the quartz glass is reduced; through the injection of gas molecules, the helium permeability of the quartz glass is lowered; and through color center control technology, the irradiation resistance of the quartz glass is enhanced. Ultimately, the doping and molecular injection process parameters for low-permeability helium quartz glass are determined, leading to the production of low-permeability helium quartz glass, thereby improving the precision, lifetime and reliability of laser gyroscopes used in inertial navigation.