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Fever of unknown origin is sometimes due to various connective tissue diseases/non-infectious inflammatory diseases. The proportion of this group of diseases in FUO has increased in recent years, accounting for about 20%–30%. Common causes include rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), adult-onset Still’s disease (AOSD), vasculitis, dermatomyositis/polymyositis (DM/PM), mixed connective tissue disease, etc. Due to the development of sensitive laboratory diagnostic tests (including antinuclear and anti-DNA markers), rheumatic/noninfectious inflammatory are easier to diagnose. The diagnosis is now usually made within 3 weeks. However, the trend of aging results in increasing of the incidence of rare diseases, such as dermatomyositis/polymyositis and temporal arteritis in elderly patients.

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Fever of Unknown Origin in Noninfectious Inflammatory Diseases

  • 章节

  • 发表日期：

    2025年

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  • Jin Jialin,
  • Chen Mingquan,
  • Yang Feifie,
  • Chen Shu,
  • Huang Yuxian,
  • Bao Suxia,
  • Zheng Jianming,
  • Li Ning,
  • Zhang Jiming,
  • Fan Qingqi,
  • Jia Wen,
  • Shao Lingyun,
  • Zhang Wenhong,
  • Liu Yuanyuan,
  • Qin Yanli,
  • Zhang Shu,
  • Hu Yuekai,
  • Zhang Yanliang,
  • Ruan Qiaoling,
  • Wu Jing,
  • Wang Xinyu

摘要

Fever of unknown origin is sometimes due to various connective tissue diseases/non-infectious inflammatory diseases. The proportion of this group of diseases in FUO has increased in recent years, accounting for about 20%–30%. Common causes include rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), adult-onset Still’s disease (AOSD), vasculitis, dermatomyositis/polymyositis (DM/PM), mixed connective tissue disease, etc. Due to the development of sensitive laboratory diagnostic tests (including antinuclear and anti-DNA markers), rheumatic/noninfectious inflammatory are easier to diagnose. The diagnosis is now usually made within 3 weeks. However, the trend of aging results in increasing of the incidence of rare diseases, such as dermatomyositis/polymyositis and temporal arteritis in elderly patients.