This article presents a comparative structural analysis of two housing typologies: one composed of reinforced concrete and the other of steel frame structures. The structural design was carried out using the force-based design method (DBF), considering the seismic and geotechnical parameters of the study area, obtained through SPT tests and bibliographic sources. The fundamental period of both structures was determined, and the corresponding response spectrum was generated, enabling the structural design and subsequent load descent according to the NEC-2015 combinations. In the foundation stage, three viable alternatives were proposed: isolated footing, combined footing, and mat foundation. Using the specialized software SAFE 2016, the performance of each option was evaluated based on soil pressure, punching shear resistance, and settlement behavior. Finally, a cost-benefit analysis was performed, considering concrete volumes and steel quantities, to select the most technically and economically suitable structural and foundation system for the study area.