Inherited Reticulate Pigmentary Disorders

Reticulate pigmentary disorders (RPDs) are a diverse group of skin conditions characterized by net-like, sieve-like, or chicken wire-like configurations of lesions. They present with hypopigmented and hyperpigmented macules of varying size and extent of pigment. RPDs include both inherited and acquired skin disorders. The inherited RPDs (IRPDs) variants are mostly autosomal dominant, with a few sporadic cases. IRPDs carry significant systemic implications, with multiorgan involvement, necessitating early clinical recognition to guide disease management and family/genetic counseling. Dermoscopy, histopathological examination, and molecular genetic testing are essential diagnostic modalities that enable accurate disease classification and prognostic stratification. Sun protection, topical depigmenting agents, topical and oral retinoids, and topical keratolytics reduce the hyperpigmentation. Lasers like Q-switched Nd: YAG, Er:YAG, Q-switched ruby, and alexandrite lasers provide temporary clinical benefit. These conditions are progressive and resistant to treatment.