Malnutrition is a serious concern in developing countries due to the nonavailability of nutritious food. Crops are major sources of human energy because they are sources of bioactive compounds, minerals, and vitamins as natural sources. In underprivileged communities, nutrient deficiency is a major threat to children, pregnant women, and younger people due to lack of nutritious food, leading to a compromise in human health. The key issue influencing human health in developing countries is nutrient-deficient foods as a source of consumption from field and horticultural crops. Fortification of food with bio-stimulants and fertilizers is a potential way to enrich food naturally with nutrients. Overexposure to the present chemical fertilizers increses the risk of diseases, unfit for human consumption, and environmental pollution, low nutrient uptake without inadequate assimilation capacity. Nanotechnology applications may help improve the nutritive value of food crops through biofortification as plants readily acquire nano-based nutrients due to their small size and higher entrapment efficiency. Nanofertilizers offer several advantages over traditional methods, including maximum bioavailability, controlled release, and a high half-life that can be retained for long periods, and prevent it from leaching in soil. Combining biofortification with nanotechnology can increase nutrient efficiency with a great impact. Further, this chapter highlights the potential use of biosynthesized nanobiofertilizers and nanonutrients, enhancing agronomic biofortification to achieve better nutritive food with sustainable practices.