In this study, high-performance concrete is C60 grade environmentally active concrete. In addition to the aggregate mixture, such as C60 grade high-performance concrete, a small amount of L-Arginine - an amino acid - is mixed to minimize the harmful effects of concrete on the natural environment and sustainably develop the ecological system. L-arginine mixed in concrete slowly dissolves into water through the hardened concrete surface, promoting the growth of microalgae attached to the concrete surface, enhancing the food chain for aquatic organisms, and promoting the growth process. Absorb carbon dioxide (CO2) produced during photosynthesis by algae. This type of concrete is a material of interest in constructing coastal, sea, and island structures in coastal areas that need to be preserved or restored to the environmental ecosystem. The quality of C60 environmentally activated concrete depends on general factors such as preparation techniques, compaction process uniformity, and additives’ amount and suitability. The present paper investigates the effect of L-Arginine as an additive on water requirement, setting time, and properties with PC cement samples. Compressive strength tests of reference cement and cement with L-Arginine at ages 3, 7, 14, and 28 days were performed according to TCVN 3118:2022. The samples were mixed by incorporating different amounts of L-Arginine (1, 3, 5, and 7%) into the water-cement mixture. The results show that L-Arginine has a negative effect on setting time, slump, water demand, and compressive strength compared to regular C60 high-strength concrete. From there, the article shows that the L-Arginine content is suitable for C60 high-performance environmentally active concrete used for projects in coastal areas that need to preserve or restore ecosystems.