Generative AI and LLMs require significant computing performance. When used in critical applications like UAVs, UGVs, and other edge devices, they additionally need strong safety and security assurances. A zero-trust SoC hardware platform is crucial for delivering the necessary performance to execute advanced ML models while ensuring safe operation and securing data communication and computation. We propose a zero-trust SoC platform to support the deployment and operation of generative AI and LLMs based on (i) a zero-trust system interconnect, (ii) hardware-level fine-grained real-time analysis, (iii) fault-tolerance in on-chip communications and computation; and (iv) advanced mitigations for side-channel attacks. Our proposal is based on several research projects published in top-notch conferences and journals, a collaboration in a relevant SoC project, and collaborations with relevant industrial partners. Our proposal is based on research projects published in top-notch conferences and journals, a collaboration in a relevant SoC project, and partnerships with relevant industrial partners.