Physiological Modeling with Dynamic Systems
摘要
Diabetes is a chronic lifelong disease that can lead to chronic tissue damage, neuropathy, and functional impairments in the body. Specific complications include diabetic nephropathy, diabetic foot, diabetic cerebrovascular disease, diabetic ketoacidosis, diabetic retinopathy, and diabetic heart disease. According to the World Health Organization (WHO) and the International Diabetes Federation (IDF), in 2019, approximately 415 million people worldwide between the ages of 20 and 79 had diabetes, with a prevalence rate of 9.3%. The average growth rate was 51%, and it is estimated that by 2045, there will be 700 million people with diabetes globally (García-Jiménez et al., Brit J Cancer 114(7):716–722, 2016). With the development of the world economy and population aging, the high disability and mortality rates associated with diabetes have become one of the fastest-growing major social issues in the twenty-first century (Lean et al., Lancet 391(10120):541–551, 2018; Tsilidis et al., Bmj 350, 2015).