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This chapter introduces twin-navigator-based multi-shot acquisition 3D oscillating gradient prepared gradient and spin echo (3D OGprep-GRASE) and pulsed gradient prepared gradient and spin echo (3D PGprep-GRASE) sequences for whole-brain time-dependent diffusion MRI (TDDMRI) on a clinical 3 T system. Building upon the single-shot sequences from Chap. 3 , this development aims to overcome the limitation of obtaining whole-brain data. The newly proposed sequences incorporate twin 1D and 2D navigator acquisition schemes to effectively correct phase errors inherent in multi-shot acquisitions. Experimental results demonstrated that navigator-based phase correction significantly reduced artifacts in DWI images. Compared to conventional 2D EPI sequences, the 3D GRASE sequences showed significantly higher image signal-to-noise ratio (SNR). Furthermore, the study revealed that the 3D sequences could discover more abundant cortical fibers and a higher fiber bundle cross-sectional area in the corticospinal tract in fiber tracking and microstructure parameter estimation compared to 2D EPI. These findings highlight the potential of the proposed 3D GRASE sequences for advanced whole-brain TDDMRI research and neuroscience applications.

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Twin-Navigator based 3D Gradient and Spin Echo Imaging

  • 章节

  • 发表日期：

    2025年

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  • Dan Wu,
  • Haotian Li,
  • Qinfeng Zhu,
  • Xingzhou Chen,
  • Li-Ang Xu

摘要

This chapter introduces twin-navigator-based multi-shot acquisition 3D oscillating gradient prepared gradient and spin echo (3D OGprep-GRASE) and pulsed gradient prepared gradient and spin echo (3D PGprep-GRASE) sequences for whole-brain time-dependent diffusion MRI (TDDMRI) on a clinical 3 T system. Building upon the single-shot sequences from Chap. 3 , this development aims to overcome the limitation of obtaining whole-brain data. The newly proposed sequences incorporate twin 1D and 2D navigator acquisition schemes to effectively correct phase errors inherent in multi-shot acquisitions. Experimental results demonstrated that navigator-based phase correction significantly reduced artifacts in DWI images. Compared to conventional 2D EPI sequences, the 3D GRASE sequences showed significantly higher image signal-to-noise ratio (SNR). Furthermore, the study revealed that the 3D sequences could discover more abundant cortical fibers and a higher fiber bundle cross-sectional area in the corticospinal tract in fiber tracking and microstructure parameter estimation compared to 2D EPI. These findings highlight the potential of the proposed 3D GRASE sequences for advanced whole-brain TDDMRI research and neuroscience applications.