Active individuals, particularly those frequently engaged in outdoor activities, are at a heightened risk of skin damage due to increased exposure to ultraviolet (UV) radiation. This study focuses on optimizing a retinoic acid-loaded nanosponge formulation, aimed at protecting the skin from UV damage. Retinoic acid, a potent derivative of vitamin A, is known to combat photoaging, hyperpigmentation, and other harmful effects of UV exposure. The study investigates the influence of homogenization speeds and drying techniques on the particle size of this formulation, which directly affects its absorption and efficacy. Nanosponge formulations were prepared with retinoic acid and subjected to oven drying methods and freeze-drying methods. The nanosponge was then added into a base emulgel for optimization with homogenization speeds of 2000, 3000, and 4000 rpm and subjected to a stability study at real-time and accelerated specifications. The results revealed significant variations in particle size, polydispersity index, and zeta potential with different drying methods and different homogenization speeds. The optimized formulation with optimal characteristics can deliver higher efficiency of the actives to enhance the skin’s defense against UV-related damage and maintain a healthier skin. In conclusion, the optimization of this formulation represents a significant consideration in formulating advance formulations. These small adjustments can result in formulations that could provide active individuals with a more effective solution to combat UV effects on skin.