The real-time tracking as well as patients’ surveillance is pervasive in a healthcare domain as the outcome of Internet of Things (IoT) and cloud. The incorporation of IoT with the conventional healthcare systems has enhanced the quality of services (QoS) in healthcare. However, the significant problem in which it cannot be eliminated in such incorporation is the data security which is transferred among client and server. Hence, this research proposes the novel security framework through the combination of blockchain technology with the optimized blowfish algorithm (OBA). The blockchain is utilized and exchanged to secure the integrity of the data and developed the individual device determination with the low power consumption and provides significant effectiveness. The OBA approach is utilized to enhance the confidentiality of the data while the transmission of the data to the server. The results show that the proposed OBA approach attains the accuracy of 97.84%, precision of 99.12%, recall of 98.32%, and F1-score of 98.84%, when compared to the existing method like three-layered architecture.