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Chronic wound management remains a significant clinical challenge due to the limitations of traditional treatments such as skin grafts. The present chapter explores the potential of ceramic nanofibre-based materials, particularly silica (SiO₂), as advanced scaffolds for chronic wound healing. Silica nanofibres, fabricated via electrospinning and sol–gel techniques, exhibit exceptional biocompatibility, high surface-area-to-volume ratio, and tunable physicochemical properties that mimic the extracellular matrix (ECM) of skin tissue. The chapter highlights key synthesis methods, including self-assembly, phase separation, and polymer-assisted electrospinning, while addressing challenges such as fibre uniformity, mechanical stability, and controlled degradation. Characterization techniques such as scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), and swelling tests are discussed to evaluate the structural and functional properties of silica nanomats. Additionally, the chapter emphasizes the material’s dynamic wettability, which transitions from hydrophobic to hydrophilic under ambient conditions, enhancing its suitability for wound dressings. Future directions include optimizing mechanical properties, integrating bioactive agents, and scaling production for clinical applications. Silica-based nanofibrous ceramics represent a promising platform for regenerative medicine, offering multifunctional solutions for chronic wound care and beyond.

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Ceramic Nanofibre-Based Materials for Chronic Wounds: Emphasis on Silica Based Material

  • 章节

  • 发表日期：

    2025年

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  • Rajrupa Bhattacharjee,
  • Lopamudra Bhattacharjee,
  • Rama Ranjan Bhattacharjee

摘要

Chronic wound management remains a significant clinical challenge due to the limitations of traditional treatments such as skin grafts. The present chapter explores the potential of ceramic nanofibre-based materials, particularly silica (SiO₂), as advanced scaffolds for chronic wound healing. Silica nanofibres, fabricated via electrospinning and sol–gel techniques, exhibit exceptional biocompatibility, high surface-area-to-volume ratio, and tunable physicochemical properties that mimic the extracellular matrix (ECM) of skin tissue. The chapter highlights key synthesis methods, including self-assembly, phase separation, and polymer-assisted electrospinning, while addressing challenges such as fibre uniformity, mechanical stability, and controlled degradation. Characterization techniques such as scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), and swelling tests are discussed to evaluate the structural and functional properties of silica nanomats. Additionally, the chapter emphasizes the material’s dynamic wettability, which transitions from hydrophobic to hydrophilic under ambient conditions, enhancing its suitability for wound dressings. Future directions include optimizing mechanical properties, integrating bioactive agents, and scaling production for clinical applications. Silica-based nanofibrous ceramics represent a promising platform for regenerative medicine, offering multifunctional solutions for chronic wound care and beyond.