Which is the most efficient method of weaning from mechanical ventilation? This multicenter, randomized trial compared four different methods for weaning patients off mechanical ventilation in the ICU. The methods compared were intermittent mandatory ventilation, pressure support ventilation, intermittent spontaneous breathing trials (SBT) carried out two or more times a day, or once daily SBT through a T-piece. The study found that there was no significant difference in mortality, but patients weaned using a once daily SBT strategy were more likely to have a shorter duration of mechanical ventilation compared to other methods—extubation occurred thrice as quickly compared with intermittent mandatory ventilation and twice as quickly compared with pressure support ventilation.