Does intensive glucose control lead to improved outcomes in the surgical ICU? The study by Van den Berghe et al. investigated the effects of intensive insulin therapy in surgical ICU patients. The trial showed that maintaining strict blood glucose control (targeting a glucose level of 80–110 mg/dL) led to improved outcomes, including reduced mortality, fewer infections, and less organ dysfunction compared to conventional insulin therapy. However, the study also raised concerns about the risk of hypoglycemia, which can have serious consequences. Despite these concerns, the overall findings supported the benefits of tight glycemic control in ICU settings.