What is the effect of hypothermia versus normothermia on outcomes in patients after out-of-hospital cardiac arrest (OHCA)? The TTM 2 trial aimed to address this question by comparing the efficacy of therapeutic hypothermia and normothermia in improving survival and neurological outcomes in patients who survived OHCA. In this large, multicenter, randomized controlled trial, 1848 patients who had been resuscitated after OHCA with an initial rhythm of either shockable or non-shockable were randomly assigned to either a hypothermia group (target temperature 33 °C) or a normothermia group (target temperature ≤ 37.5 °C), with temperature control for 24 h followed by gradual rewarming. There was no significant difference between the groups in 6-month survival. Furthermore, there was no difference in neurological outcomes, with similar proportions of patients achieving a favorable neurological recovery. The TTM 2 trial concluded that, in patients with OHCA, targeted temperature management at 33 °C did not provide a survival or neurological benefit over normothermia. These findings further reinforced the importance of normothermic management post-cardiac arrest, shifting the paradigm toward less aggressive cooling strategies in clinical practice.