Four decades on, HIV has transformed into a chronic condition. Similar to chronic illnesses’ management, the success of HIV management and well-being of patients living with HIV depend on the support that the patients receive, as well as their engagement in self-management activities. With the advent of COVID-19, there was a considerable disruption in the provision of care, and that had a negative effect on the well-being of people living with HIV (PLWH). As a result of regulations, access to health services was reduced. In institutions where patients had the opportunity to support each other in support groups, such gatherings were discontinued in an effort to ensure social distancing. The healthcare system diverted all the effort towards COVID-19, and as a result, the risk of loss to follow-up was increased, and access to medication needed was impacted. The isolation and social distancing required to reduce the risk of COVID-19 transmission caused the isolation of patients from their own social networks. Not only did they lose support from healthcare providers, but they also lost connection and support from their own social networks. Mental well-being is an important aspect of the overall well-being of PLWH, and isolation is one of the aspects that would negatively affect their well-being. Similarly, the regulations related to the hard lockdown where people were limited in their movements also brought an additional risk for PLWH as an active lifestyle is important in maintaining well-being. COVID-19 also brought a huge financial challenge to the communities. Opportunities for employment were reduced, a number of people lost their jobs, and those involved in small businesses and other informal activities were not able to earn an income through their businesses. Lack of financial means has a great impact on people living with HIV as they need to be able to provide food for themselves and their families.