Lifestyle diseases are caused due to the habits or manners a person adopts in his/her life. These diseases are non-contagious, caused by unhealthy practices, unhealthy diet and physical inactivity. Their early symptoms need to be addressed carefully and seriously with clinical interventions if needed. Certain environmental toxicants and pollutants are known to aggravate these lifestyle diseases. Toxic air pollutants and particulate matter are known to initiate and aggravate some major lifestyle diseases like lung cancer, heart disease, asthma, stroke and chronic obstructive pulmonary disease (COPD). Therapies for mitigating these lifestyle disorders include modification in lifestyle, changing daily habits, good diet, exercise, and some conventional medicines. Bioactive phytocompounds are always a better alternative choice to combat health issues as they come with no cytotoxicity, side effects and also work efficiently in a unique manner. These phytochemicals are natural compounds having potent beneficial roles against air pollutant-aggravated lifestyle diseases. Their mechanism of action is multifaceted and also known to work to enhance the impact of conventional drugs. Most of these bioactive phytocompounds are antioxidants and thus have an overall health benefit when administered in a specific dose.