Morphea is a chronic inflammatory disorder characterized by localized skin and subcutaneous sclerosis, with potential extracutaneous involvement in up to 25% of cases. The disease exhibits a broad clinical spectrum, from isolated plaques to severe, generalized forms leading to disfigurement and functional impairment. Clinically, morphea presents with progressive skin thickening, pigmentary changes, and, in some cases, musculoskeletal, neurological, ocular, and oral complications. The German classification system categorizes it into various subtypes, including circumscribed, generalized, and linear morphea. Differential diagnoses depend on disease stage, with systemic sclerosis being a key exclusion.

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Morphea

  • Sudip Ghosh,
  • Sharmistha Panja,
  • Partha Mukherjee

摘要

Morphea is a chronic inflammatory disorder characterized by localized skin and subcutaneous sclerosis, with potential extracutaneous involvement in up to 25% of cases. The disease exhibits a broad clinical spectrum, from isolated plaques to severe, generalized forms leading to disfigurement and functional impairment. Clinically, morphea presents with progressive skin thickening, pigmentary changes, and, in some cases, musculoskeletal, neurological, ocular, and oral complications. The German classification system categorizes it into various subtypes, including circumscribed, generalized, and linear morphea. Differential diagnoses depend on disease stage, with systemic sclerosis being a key exclusion.