Scholarlink

The chapter explores the complex molecular mechanisms that cause autoimmune illnesses when the immune system erroneously targets body tissues. It clarifies basic ideas such as the processes of immunological tolerance and the interaction between genetic predisposition and environmental triggers in the development of autoimmune illnesses. This chapter analyzes the molecular processes implicated in the progression of autoimmune disorders, with specific emphasis on signaling pathways such as NF-κB, JAK-STAT, and PI3K-Akt. These cascades regulate the activation of immune cells, the production of cytokines, and initiation of inflammatory responses. This chapter investigated the influence of dysregulation of these pathways on the occurrence of immune system failure and tissue damage, which are typical features of autoimmune diseases. Furthermore, it explored the impact of epigenetic changes and noncoding RNAs on the regulation of autoimmune gene expression. This chapter aimed to clarify the processes by which autoimmune responses are controlled beyond the exclusive influence of hereditary factors. Scientists are conducting thorough investigations into the role of several biological elements, such as dendritic cells, macrophages, T cells, and B cells, in the development and progression of autoimmune diseases. The succeeding chapters provide a detailed understanding of how things work with specific autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus (SLE), multiple sclerosis, and type 1 diabetes. This chapter provides a comprehensive explanation of the underlying mechanisms of these diseases and the potential therapeutic approaches. This chapter aims to enhance the understanding of autoimmune diseases among scholars, medical practitioners, and students by integrating state-of-the-art research from a clinical perspective. This chapter promotes the use of personalized medical strategies and emphasizes the revolutionary impact of emerging technology on improving the diagnosis and treatment of autoimmune diseases in the age of precision medicine.

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Molecular and Cellular Mechanisms Underlying Autoimmune Pathologies

  • 章节

  • 发表日期：

    2025年

查看全文
  • Hahyeong Jang,
  • Siyoung Yang

摘要

The chapter explores the complex molecular mechanisms that cause autoimmune illnesses when the immune system erroneously targets body tissues. It clarifies basic ideas such as the processes of immunological tolerance and the interaction between genetic predisposition and environmental triggers in the development of autoimmune illnesses. This chapter analyzes the molecular processes implicated in the progression of autoimmune disorders, with specific emphasis on signaling pathways such as NF-κB, JAK-STAT, and PI3K-Akt. These cascades regulate the activation of immune cells, the production of cytokines, and initiation of inflammatory responses. This chapter investigated the influence of dysregulation of these pathways on the occurrence of immune system failure and tissue damage, which are typical features of autoimmune diseases. Furthermore, it explored the impact of epigenetic changes and noncoding RNAs on the regulation of autoimmune gene expression. This chapter aimed to clarify the processes by which autoimmune responses are controlled beyond the exclusive influence of hereditary factors. Scientists are conducting thorough investigations into the role of several biological elements, such as dendritic cells, macrophages, T cells, and B cells, in the development and progression of autoimmune diseases. The succeeding chapters provide a detailed understanding of how things work with specific autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus (SLE), multiple sclerosis, and type 1 diabetes. This chapter provides a comprehensive explanation of the underlying mechanisms of these diseases and the potential therapeutic approaches. This chapter aims to enhance the understanding of autoimmune diseases among scholars, medical practitioners, and students by integrating state-of-the-art research from a clinical perspective. This chapter promotes the use of personalized medical strategies and emphasizes the revolutionary impact of emerging technology on improving the diagnosis and treatment of autoimmune diseases in the age of precision medicine.