With the appearance of public health emergencies, which are endemics and chronic disease outbreaks, the value of healthcare interventions secures the efficient management of massive volumes of sensitive data. Traditional healthcare systems are frequently challenged with issues of data integrity and privacy breaches, as well as a lack of transparency and incompetent coordination among the stakeholders. This research explores the integration of blockchain-enabled digital therapeutics (DTx) platforms to improve the management of public health emergencies. The blockchain’s decentralized, secure, and transparent nature with the proposed platform aims to address critical challenges in current healthcare systems, like data integrity, privacy, and real-time monitoring. The platform’s architecture, which includes blockchain network user boundaries and DTx applications, is severely tested in simulated environments and represents its effectiveness in securely handling large volumes of health data during emergencies. The study highlights the potential of blockchain-enabled DTx platforms to reform public health responses while also identifying future research directions and addressing challenges related to large-scale adoptions, including regulatory compliance, scalability, and interoperability.