Biological waste derives from biological activities, including waste from plants, animals, hospitals, homes, and municipal solid waste. It disrupts soil health as well as biodiversity, contributing to global warming and climate change. Biological waste management involves collecting waste from its origins, transporting it, processing it, disposing of it, or recycling it for further renewable energy. Biological waste management is crucial for creating a pollution-free environment and conserving nutrient resources for crop production. This waste management involves physical, chemical, and biological methods. Physical methods involve (i) incineration, (ii) pyrolysis, and (iii) gasification, which undergo dynamic chemical transformation of solid fuel into a lower amount of waste. Chemical methods include ion exchange, precipitation, oxidation, reduction, and neutralization processes for hazardous biomedical waste management. Biological methods involve the transformation of waste by living organisms to produce stable organic matter. Proper treatment of biological waste is essential for environmental conservation. The bioconversion of waste into renewable energy sources such as biogas, biodiesel, and bioethanol can reduce greenhouse gas emissions. The current chapter discusses the management of biological wastes through the use of physical, chemical, and biological methods.