Clinical governance translates quality principles into everyday practice and culture. Positioned after foundational quality concepts, it ensures that high standards of care are applied consistently, using the right tools such as clinical audit, evidence-based guidelines, measurement, and learning systems. This chapter sets out a structured framework that integrates all quality domains, including ethics, confidentiality, data protection, and legal compliance, to provide clear oversight and continuous improvement in safety and outcomes. We detail leadership’s role in setting priorities, resourcing teams, and modeling accountability and outline practical methods for clinical risk assessment and risk management: identifying hazards, analyzing root causes, implementing controls, and monitoring residual risk. By aligning strategy, governance, and frontline work, clinical governance makes quality and patient safety a reliable, organization-wide habit.