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Pancytopenia, characterized by the simultaneous reduction of hemoglobin, neutrophils, and platelets below critical levels, is a significant clinical concern in the ICU. It reflects a broad spectrum of pathophysiological processes ranging from bone marrow suppression to peripheral destruction of blood elements. Effective management requires a systematic approach to diagnosis and treatment, as the causes can range from nutritional deficiencies to life-threatening conditions like disseminated intravascular coagulation (DIC) or hemophagocytic lymphohistiocytosis (HLH). This chapter provides a comprehensive approach to pancytopenia in critically ill patients, incorporating advanced diagnostic tools, management strategies, and considerations for special populations and emerging conditions [1, 2] [Ref: Algorithm 93.1].

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Approach to Pancytopenia in the ICU

  • 章节

  • 发表日期：

    2025年

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  • Shakti Bedanta Mishra,
  • Samir Samal,
  • Sagarika Panda

摘要

Pancytopenia, characterized by the simultaneous reduction of hemoglobin, neutrophils, and platelets below critical levels, is a significant clinical concern in the ICU. It reflects a broad spectrum of pathophysiological processes ranging from bone marrow suppression to peripheral destruction of blood elements. Effective management requires a systematic approach to diagnosis and treatment, as the causes can range from nutritional deficiencies to life-threatening conditions like disseminated intravascular coagulation (DIC) or hemophagocytic lymphohistiocytosis (HLH). This chapter provides a comprehensive approach to pancytopenia in critically ill patients, incorporating advanced diagnostic tools, management strategies, and considerations for special populations and emerging conditions [1, 2] [Ref: Algorithm 93.1].