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Acute respiratory distress syndrome (ARDS) is a life-threatening condition marked by severe hypoxemia and decreased lung compliance due to diffuse alveolar damage. Mechanical ventilation is a cornerstone in the management of ARDS; however, inappropriate ventilator settings can exacerbate lung injury, leading to ventilator-induced lung injury (VILI). Over the past decades, ventilation strategies in ARDS have evolved significantly, shifting from high tidal volume (VT) approaches to protective ventilation strategies aimed at minimizing VILI. Landmark studies, such as the ARDSNet trial, have established the use of low VT (6 mL/kg predicted body weight [PBW]) as standard care, significantly reducing mortality and improving patient outcomes [1, 2] [Ref: Algorithm 78.1].

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Approach to Setting Tidal Volume in ARDS Patients in the ICU

  • 章节

  • 发表日期：

    2025年

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  • Shakti Bedanta Mishra,
  • Samir Samal,
  • Sagarika Panda

摘要

Acute respiratory distress syndrome (ARDS) is a life-threatening condition marked by severe hypoxemia and decreased lung compliance due to diffuse alveolar damage. Mechanical ventilation is a cornerstone in the management of ARDS; however, inappropriate ventilator settings can exacerbate lung injury, leading to ventilator-induced lung injury (VILI). Over the past decades, ventilation strategies in ARDS have evolved significantly, shifting from high tidal volume (VT) approaches to protective ventilation strategies aimed at minimizing VILI. Landmark studies, such as the ARDSNet trial, have established the use of low VT (6 mL/kg predicted body weight [PBW]) as standard care, significantly reducing mortality and improving patient outcomes [1, 2] [Ref: Algorithm 78.1].