Pulmonary embolism (PE) is a potentially life-threatening condition resulting from the obstruction of the pulmonary arteries, most commonly due to thromboemboli originating from deep vein thrombosis (DVT). In the intensive care unit (ICU), prompt recognition and appropriate management are essential to reduce mortality and morbidity. This chapter provides a comprehensive approach for diagnosing and managing PE in critically ill patients, integrating the latest clinical guidelines, evidence-based recommendations, and special considerations for various patient populations [1, 2] [Ref: Algorithm 73.1].