Hyperthyroidism in the ICU is a complex and potentially life-threatening condition, particularly in patients experiencing severe thyroid hormone excess, such as in thyroid storm. Early diagnosis and appropriate management are crucial to stabilizing the patient and mitigating risks associated with thyrotoxicosis, including cardiovascular, neurological, and metabolic complications. This chapter provides a detailed approach to managing hyperthyroidism in critically ill patients, emphasizing the assessment of severity, rapid symptom control, and addressing underlying etiologies [1, 2]. [Ref: Algorithm 50.1].