Acute pancreatitis (AP) is an inflammatory condition that varies in severity, from mild cases with rapid recovery to severe forms leading to necrosis, infection, and multi-organ failure. Chronic pancreatitis (CP), on the other hand, is a long-standing inflammation that results in fibrosis and the irreversible loss of pancreatic function, often requiring a different management strategy. Early intervention, appropriate diagnosis, and treatment in the ICU are essential to minimize morbidity and mortality. This chapter provides a structured, evidence-based approach for managing both acute and chronic pancreatitis, with an emphasis on ICU-level care and chronic management [1] [Ref: Algorithm 34.1].