Hypercalcemia, defined as an abnormally elevated level of calcium in the blood, is a common electrolyte disorder with significant clinical consequences. Calcium plays a crucial role in various physiological processes, including neuromuscular function, blood coagulation, and bone metabolism. In the bloodstream, calcium exists in three distinct fractions: ionized calcium (approximately 50%), which is the biologically active form; protein-bound calcium, primarily attached to albumin (about 40%); and calcium complexed with anions like phosphate and citrate (around 10%). The management of hypercalcemia, especially in the intensive care unit (ICU), is critical because severe cases can lead to life-threatening complications such as cardiac arrhythmias, renal failure, and neurological impairments [1].

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Approach to Hypercalcemia in the ICU

  • Shakti Bedanta Mishra,
  • Samir Samal,
  • Sagarika Panda

摘要

Hypercalcemia, defined as an abnormally elevated level of calcium in the blood, is a common electrolyte disorder with significant clinical consequences. Calcium plays a crucial role in various physiological processes, including neuromuscular function, blood coagulation, and bone metabolism. In the bloodstream, calcium exists in three distinct fractions: ionized calcium (approximately 50%), which is the biologically active form; protein-bound calcium, primarily attached to albumin (about 40%); and calcium complexed with anions like phosphate and citrate (around 10%). The management of hypercalcemia, especially in the intensive care unit (ICU), is critical because severe cases can lead to life-threatening complications such as cardiac arrhythmias, renal failure, and neurological impairments [1].