Delirium is a frequent and severe condition in the intensive care unit (ICU), marked by sudden disturbances in attention and cognition. It significantly worsens patient outcomes, including extended ICU stays, higher mortality, and potential long-term cognitive impairment. Delirium management in the ICU requires a comprehensive strategy that incorporates early detection, addressing reversible causes, and the judicious use of both non-pharmacologic and pharmacologic treatments [1, 2] (Ref. Algorithm 15.1).