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Gram-negative multidrug-resistant organisms (MDROs) pose a significant challenge in intensive care units (ICUs) due to their capacity to resist multiple classes of antibiotics. Organisms such as extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-E), carbapenem-resistant Enterobacterales (CRE), Pseudomonas aeruginosa, and Acinetobacter baumannii are associated with increased morbidity, mortality, and healthcare costs. The emergence of extensively drug-resistant (XDR) pathogens necessitates a comprehensive approach that includes updated susceptibility testing, optimized antimicrobial therapy, and preventive strategies. Prompt identification and individualized management are critical to improving patient outcomes [1, 2] [Ref: Algorithm 100.1].

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Approach to Gram-Negative Multidrug-Resistant Organisms (MDROs) in the ICU

  • 章节

  • 发表日期：

    2025年

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  • Shakti Bedanta Mishra,
  • Samir Samal,
  • Sagarika Panda

摘要

Gram-negative multidrug-resistant organisms (MDROs) pose a significant challenge in intensive care units (ICUs) due to their capacity to resist multiple classes of antibiotics. Organisms such as extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-E), carbapenem-resistant Enterobacterales (CRE), Pseudomonas aeruginosa, and Acinetobacter baumannii are associated with increased morbidity, mortality, and healthcare costs. The emergence of extensively drug-resistant (XDR) pathogens necessitates a comprehensive approach that includes updated susceptibility testing, optimized antimicrobial therapy, and preventive strategies. Prompt identification and individualized management are critical to improving patient outcomes [1, 2] [Ref: Algorithm 100.1].