In current years, Zinc (Zn)-based biomaterials (BMs) have been considered as novel materials due to their intermediate degradation properties. Pure Zn exhibits inadequate mechanical, biocompatible properties, so to improve the performance characteristics bioceramic materials have been combined to achieve specific biocompatibility and biodegradability. In this work, Zn-Hydroxyapatite (Zn-HA) and Zn-HA-Manganese (Zn-HA-Mn) composites were synthesized using a microwave-based sintering process. The degradation effect due to the addition of HA and Mn has been checked in a simulated body fluid solution (SBF). Zn-5HA was found to have better degradation characteristics than other samples. Adding of Hydroxyapatite (HA) and Manganese (Mn) to the Zn matrix in Zn-5HA-4Mn samples led higher corrosion rate and pH levels. The rate of weight loss due to SBF immersion testing of all samples have been found from high to low: Zn-HA-Mn > Zn-HA > Zn. Further, the compression testing of the developed composites shows that Zn-HA composite exhibits higher mechanical integrity than other combinations.