This paper provides a comprehensive review of the current research on the structural, mechanical, and thermal behavior of these advanced materials and focuses on the influence of various hybrid nanofiller combinations. By incorporating nanofillers like graphene, carbon nanotubes (CNTs), and nanoclays into epoxy matrices, the resulting nanocomposites exhibit superior properties due to improved dispersion, interfacial bonding, and interactions between fillers. Epoxy-based hybrid polymer matrix nanocomposites have emerged as a transformative material class and offer remarkable improvements in mechanical, thermal, and structural properties. The review discusses the key factors influencing composite performance and includes nanofiller characteristics, fabrication methods, and hybridization strategies. The findings reveal that hybrid nanocomposites show significant improvements with tensile strength increasing up to 70%, thermal stability enhanced by 20–30 °C and thermal conductivity boosted by 60% compared to plain epoxy. Mechanisms of reinforcement—such as effective load transfer and strong interfacial adhesion are investigated in detail—highlighting the impact of surface functionalization and improved dispersion strategies. The study ends with a discussion of potential future research avenues, highlighting the necessity of standardizing material characterization and design in order to fully realize the potential of epoxy-based hybrid nanocomposites for high-performance applications in the electronic, automotive, and aerospace industries.