This chapter brings together the insights on reading, science and fiction generated by our analyses in Chaps. 2 , 3 , and 4 , and extends our discussion on methods, readers and engagement. We return to the projects that generated our empirical data to consider the epistemologies, methods and relationships that make social research with embodied readers and everyday reading practices possible. We reflect on the limits of our findings and on some of the missteps and misapprehensions that shaped our meetings with readers along the way. We argue that there is no simple and straightforward way to conduct research on reading and science. We suggest instead that multiple methods are needed to generate different kinds of insights into who readers are, what they do, and why it matters. We consider ways of thinking about reading science/fiction in the context of contemporary debates about science communication in an age of plural audiences and multiple modes of engagement.