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Cuproptosis, a novel type of cell death. However, the prognostic of cuproptosis-related genes (CRGs) in SKCM remains unexplored. In the study, through univariate Cox, Lasso, and multivariate Cox regression analyses, 8 CRGs were selected to build the prognostic prediction model. The area under the curve for the prediction of 5-year overall survival in the training dataset is 0.825, while in the test dataset, it is 0.75. Besides, low risk group exhibits a high abundance of immune cells. In conclusion, CRGs could effectively predict the prognosis of SKCM patients, and may provide novel insights into the cancer treatment.

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Cuproptosis-Related Genes Are Correlated with Prognostic and Immune Infiltration in Skin Cutaneous Melanoma Patients

  • 会议论文

  • 发表日期：

    2025年

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  • Di Zhang,
  • Ying Liang,
  • Wenquan Li

摘要

Cuproptosis, a novel type of cell death. However, the prognostic of cuproptosis-related genes (CRGs) in SKCM remains unexplored. In the study, through univariate Cox, Lasso, and multivariate Cox regression analyses, 8 CRGs were selected to build the prognostic prediction model. The area under the curve for the prediction of 5-year overall survival in the training dataset is 0.825, while in the test dataset, it is 0.75. Besides, low risk group exhibits a high abundance of immune cells. In conclusion, CRGs could effectively predict the prognosis of SKCM patients, and may provide novel insights into the cancer treatment.