Encapsulation of Chromolaena odorata and Liposome for Drug Delivery

The Chromolaena odorata (Pokok Kapal Terbang) has significant high contents of flavonoid, phenolic and antibacterial agent. The Soxhlet extraction method was utilized using solvent ethanol and hexane. This study focused on encapsulation of C. odorata with liposome and particularly a crude extract as ethanol-C. odorata extract (COET) and hexane-C. odorata extract (COHE). The identification of specific fragments in COET and COHE by utilizing Thin Layer Chromatography (TLC). The result revealed that liposome-COHE and liposome-COET have a bigger size on its diameter size comparison with liposome, which is 35.16 μm > 34.89 μm > 8.178 μm, respectively. A degradation investigation demonstrated that with a liposome encapsulated, this Li-COET and Li-COHE are capable to preserve releasing its active compounds after 6 h, and capable of reaching its target area notably for gastrointestinal treatment. This finding demonstrates an encapsulated Li-COET and Li-COHE are suitable for drug delivery system and a future work require to evaluate the efficiency of its activities.