Preparation and Research of Copper-Doped Collagen/Hydroxyapatite Controlled Assembly Bone Repair Materials

With the widespread application of biomaterials in the medical field, research on bone defect repair materials has become particularly important. Hydroxyapatite (HA) has been extensively studied due to its excellent biocompatibility and osteoconductivity, while collagen (Col), as the main organic component of bone tissue, plays a critical role in bone formation and repair. Copper ions (Cu2+) can enhance angiogenesis and bone regeneration in vivo by promoting the proliferation of endothelial cells. In this study, copper-doped mineralized collagen (Cu-MC) bone repair material was prepared via a controlled assembly method, and the lattice substitution mechanism was investigated to effectively regulate the crystal structure and physicochemical properties of the material. Cu-MC with 1, 5, and 10% copper doping was synthesized using a chemical precipitation method. The results confirmed the successful incorporation of copper, which improved the thermal stability and structural rigidity of the material while preserving its original morphology. This material shows promise as an ideal bone substitute, offering a superior option for bone defect repair.