Construction and Performance Optimization of Glucose Sensing Electrode Based on PEG/TPU Composite Membrane and Nafion Anti-Interference Layer
摘要
In this study, we developed a high-sensitivity implantable glucose sensor by constructing a synergistic architecture comprising a PEG/TPU composite membrane and a Nafion anti-interference layer. To enhance sensor stability and sensitivity, we systematically investigated glucose sensing responses under different PEG:TPU ratios, and coated with Nafion to improve anti-interference capability and long-term stability. The results indicate that the composite electrode with PEG:TPU = 1:3 and a three-layer membrane structure exhibits optimal glucose response performance: in the 0–30 mM glucose range, sensitivity is 5.533 nA/mM, linearity (R2) is 0.994, and response time is 25 s. Additionally, the sensor demonstrates good anti-interference performance and excellent in vitro stability over 24 days.