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Notch signaling is initially identified to play an important role in the developmental control. In Notch signaling pathway of Caenorhabditis elegans, activation of both Notch ligand LAG-2 and Notch receptor GLP-1 mediated transgenerational pollutant toxicity. During this process, TAF-1 and HDA-3 were identified as upregulators for LAG-2 in the germline, and potential transgenerational communication between germline LAG-2 and its receptor GLP-1 may exist. GLP-1 could further act in germline and neurons to regulate the transgenerational pollutant toxicity by affecting certain downstream targeted genes.

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Regulation of Transgenerational Toxicity by Transgenerational Communication of Germline Notch Signals

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  • 发表日期：

    2026年

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  • Dayong Wang

摘要

Notch signaling is initially identified to play an important role in the developmental control. In Notch signaling pathway of Caenorhabditis elegans, activation of both Notch ligand LAG-2 and Notch receptor GLP-1 mediated transgenerational pollutant toxicity. During this process, TAF-1 and HDA-3 were identified as upregulators for LAG-2 in the germline, and potential transgenerational communication between germline LAG-2 and its receptor GLP-1 may exist. GLP-1 could further act in germline and neurons to regulate the transgenerational pollutant toxicity by affecting certain downstream targeted genes.