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Fibroblast growth factor (FGF) signaling pathway is a conserved signaling pathway. The role of FGF ligand EGL-17 in the germline and its several upregulators in regulating transgenerational pollutants toxicity was introduced. Also, the role of FGF receptor EGL-15 and its tissue-specific activity in regulating transgenerational pollutants toxicity were discussed. In intestinal cells and neurons, EGL-15 regulated transgenerational pollutants toxicity by affecting different downstream targets. Moreover, the potential transgenerational communication between germline EGL-17 and its receptor EGL-15 and its association with induction of transgenerational pollutants toxicity were discussed.

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Regulation of Transgenerational Toxicity by Transgenerational Communication of Germline FGF Signals

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  • 发表日期：

    2026年

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  • Dayong Wang

摘要

Fibroblast growth factor (FGF) signaling pathway is a conserved signaling pathway. The role of FGF ligand EGL-17 in the germline and its several upregulators in regulating transgenerational pollutants toxicity was introduced. Also, the role of FGF receptor EGL-15 and its tissue-specific activity in regulating transgenerational pollutants toxicity were discussed. In intestinal cells and neurons, EGL-15 regulated transgenerational pollutants toxicity by affecting different downstream targets. Moreover, the potential transgenerational communication between germline EGL-17 and its receptor EGL-15 and its association with induction of transgenerational pollutants toxicity were discussed.